Research Articles
Target Product Profile (TPP): The Strategic Blueprint for Successful Drug Development
This article provides a comprehensive guide to Target Product Profiles (TPPs), a critical strategic planning tool in biomedical product development.
Druggability Assessment of Molecular Targets: Methods, Applications, and Future Directions in Drug Discovery
This comprehensive review explores the critical role of druggability assessment in modern drug discovery, addressing the high attrition rates in pharmaceutical development.
Target Identification and Validation in Drug Discovery: Foundational Concepts, Advanced Methods, and Future Trends
This article provides a comprehensive overview of the critical processes of target identification and validation in modern drug discovery.
Comparative ADMET Profiling of Analogs: Strategies for Lead Optimization in 2025
This article provides a comprehensive guide for researchers and drug development professionals on the strategic application of comparative ADMET profiling for analog series. It covers foundational principles, explores cutting-edge computational methodologies like hybrid tokenization and graph-based models, addresses common troubleshooting and optimization challenges, and outlines robust validation frameworks. By integrating the latest advances in machine learning, web-based optimization tools, and experimental design, this resource aims to enhance lead optimization efficiency, reduce late-stage attrition, and accelerate the development of safer, more effective drug candidates.
Bridging the Gap: A Comprehensive Guide to In Vitro-In Vivo Correlation (IVIVC) Methods in Modern Drug Development
This article provides a comprehensive overview of In Vitro-In Vivo Correlation (IVIVC) methodologies, essential for predicting the in vivo performance of drug products based on in vitro data. Tailored for researchers, scientists, and drug development professionals, it explores the fundamental principles and regulatory definitions of IVIVC, delves into advanced methodological applications across diverse dosage forms, addresses common challenges and optimization strategies for complex formulations, and outlines rigorous validation and comparative analysis frameworks. By synthesizing the latest advancements and practical insights, this guide aims to equip professionals with the knowledge to develop robust IVIVC models, thereby accelerating formulation development, reducing regulatory burden, and minimizing the need for extensive clinical studies.
Quantum Leaps: How Quantum Simulations Are Revolutionizing Drug Discovery and Material Science
Explore how quantum simulations are transforming drug discovery and material science through advanced molecular modeling and quantum computing capabilities.
Shining a Light on Carbon Dots: The Tiny Green Gems Revolutionizing Science
Explore the fascinating world of fluorescent carbon dots - their synthesis, properties, and revolutionary applications in medicine, sensing, and environmental science.
Building Better Bones: How 3D-Printed Polyurethane Scaffolds Are Revolutionizing Bone Repair
Explore how 3D-printed polyurethane scaffolds are transforming bone tissue engineering through advanced manufacturing techniques and bioactive integration.
Nature's Painkeller: A Jungle Leaf Rivals a Pharmaceutical Giant
Discover how Ehretia laevis, a traditional medicinal plant, compares to Diclofenac in inhibiting COX enzymes for pain relief.
CRISPR: The Tiny Scissors Rewriting the Code of Life
Explore the revolutionary CRISPR gene-editing technology, from bacterial origins to groundbreaking medical applications and the latest clinical trials.