Research Articles
Beyond the Maximum Tolerated Dose: Modern Strategies for Balancing Efficacy and Toxicity in Oncology Drug Development
This article addresses the critical challenge of optimizing the therapeutic index in oncology drug development, moving beyond the traditional maximum tolerated dose (MTD) paradigm.
Validating Observational Studies with Randomized Trials: A Modern Framework for Biomedical Research
This article provides a comprehensive framework for researchers and drug development professionals seeking to validate observational study results against randomized controlled trial (RCT) data.
Beyond the Gold Standard: A Modern Framework for Evaluating Pharmaceutical Effectiveness Through RCTs and Observational Studies
This article provides a comprehensive analysis for researchers and drug development professionals on the evolving roles of Randomized Controlled Trials (RCTs) and observational studies in evaluating pharmaceutical effectiveness.
Optimizing Cancer Combination Therapy: A Comprehensive Guide to Scheduling with Optimal Control Theory
This article provides a comprehensive overview of the application of Optimal Control Theory (OCT) to optimize the scheduling of cancer combination therapies.
Beyond the Trial: A Strategic Framework to Improve RCT Generalizability for Real-World Impact
This article provides researchers, scientists, and drug development professionals with a comprehensive guide to addressing the critical challenge of generalizing Randomized Controlled Trial (RCT) findings to real-world populations.
Solving Publication Bias in Comparative Effectiveness Research: A Roadmap for Transparent Evidence
This article addresses the critical challenge of publication bias in comparative effectiveness research (CER), where statistically significant positive results are disproportionately published, distorting the evidence base.
Reducing Uncertainty in Adjusted Indirect Treatment Comparisons: A Strategic Guide for Robust Comparative Effectiveness Research
This article provides a comprehensive guide for researchers and drug development professionals on methodologies to reduce uncertainty in Adjusted Indirect Treatment Comparisons (ITCs).
Beyond Maximum Tolerated Dose: A Mathematical Modeling Approach to Optimizing Combination Therapy in Oncology
The paradigm for dosing oncology drugs is shifting from the traditional maximum tolerated dose (MTD) approach toward model-informed, optimized strategies, particularly for modern targeted therapies and immunotherapies.
Bridging the Evidence Gap: Methodological Strategies for Validating Real-World Evidence Against Randomized Controlled Trials
This article provides a comprehensive framework for researchers and drug development professionals on validating Real-World Evidence (RWE) against the gold standard of Randomized Controlled Trials (RCTs).
Managing Inconsistency in Network Meta-Analysis: A Comprehensive Guide to Detecting and Resolving Direct-Indirect Evidence Conflicts
This article provides a comprehensive guide for researchers and drug development professionals on handling inconsistency between direct and indirect evidence in Network Meta-Analysis (NMA).