Research Articles
Navigating the Lead Optimization Pipeline: Key Challenges and Advanced Solutions for Drug Discovery
This article provides a comprehensive overview of the critical challenges and state-of-the-art solutions in the lead optimization pipeline for drug discovery professionals.
Transformative AI: A Complete Guide to De Novo Drug Design
This article provides a comprehensive exploration of artificial intelligence's revolutionary role in de novo drug design for researchers, scientists, and drug development professionals.
Modern Virtual Screening Protocols in Drug Discovery: AI-Driven Methods, Applications, and Best Practices
This article provides a comprehensive overview of contemporary virtual screening protocols that are revolutionizing early drug discovery.
Strategic ADME Optimization in Lead Optimization: Accelerating Candidate Selection with Integrated Approaches
This article provides a comprehensive guide to ADME optimization in modern lead optimization, addressing the critical need to reduce late-stage attrition in drug development.
High-Throughput Screening Assay Development: A Comprehensive Guide from Foundation to Validation
This article provides a comprehensive roadmap for researchers, scientists, and drug development professionals engaged in developing robust high-throughput screening (HTS) assays.
Molecular Docking for Protein-Ligand Interactions: A Comprehensive Guide from Foundations to Advanced Applications in Drug Discovery
This article provides a comprehensive guide to molecular docking, a pivotal computational technique in structure-based drug design.
Ligand-Based Drug Design: Approaches, Applications, and Advances in Modern Drug Discovery
This article provides a comprehensive overview of Ligand-Based Drug Design (LBDD), a pivotal computational approach in modern drug discovery when the 3D structure of a biological target is unavailable.
QSAR and Pharmacophore Modeling: Advanced Techniques for Modern Drug Discovery
This article provides a comprehensive overview of Quantitative Structure-Activity Relationship (QSAR) and pharmacophore modeling, two indispensable pillars of computer-aided drug design.
Structure-Based Drug Design: From Foundational Principles to AI-Driven Discovery
This article provides a comprehensive overview of Structure-Based Drug Design (SBDD), a cornerstone of modern rational drug discovery.
Lead Compound Identification Strategies: From Foundational Concepts to Advanced AI-Driven Discovery
This article provides a comprehensive overview of modern lead compound identification strategies for researchers and drug development professionals.