Research Articles
Mastering the Shake-Flask Method: A Comprehensive Guide to logP and logD Determination in Drug Development
This article provides a complete guide to the shake-flask method, the established benchmark for determining lipophilicity via logP and logD.
RP-TLC and RP-HPTLC for Lipophilicity Measurement: A Complete Guide for Drug Development
Lipophilicity, a key determinant of a compound's absorption, distribution, metabolism, excretion, and toxicity (ADMET), is crucial in modern drug discovery.
Chromatographic Methods for Lipophilicity Determination in Drug Discovery: A Practical Guide for Researchers
Lipophilicity, quantified as logP and logD, is a fundamental physicochemical property that critically influences the absorption, distribution, metabolism, and excretion (ADME) of potential drug candidates.
Lipophilicity and Metabolic Clearance: A Strategic Guide for Optimizing Drug Properties in Discovery and Development
This article provides a comprehensive examination of the critical relationship between lipophilicity and metabolic clearance, a key determinant of drug candidate success.
Lipophilicity and Volume of Distribution: A Comprehensive Guide for Drug Development
This article provides a thorough examination of the critical relationship between drug lipophilicity (logP) and the volume of distribution (VDss), a key pharmacokinetic parameter.
Lipophilicity and hERG Toxicity Risk: A Comprehensive Guide for Safer Drug Design
Drug-induced hERG channel blockade is a leading cause of costly late-stage drug attrition due to cardiotoxicity.
Lipophilicity and BBB Penetration: From Molecular Principles to AI-Driven Drug Design
This article provides a comprehensive analysis of the critical role of lipophilicity in blood-brain barrier (BBB) penetration for central nervous system (CNS) drug development.
Strategic Design Principles for Balancing Lipophilicity and Permeability in Modern Drug Development
This article provides a comprehensive guide for researchers and drug development professionals on the critical balance between lipophilicity and permeability, a key determinant of oral bioavailability.
Lipophilicity and Plasma Protein Binding: The Critical Partnership in Drug Discovery and Development
This article provides a comprehensive analysis of the intricate relationship between lipophilicity and plasma protein binding (PPB), a cornerstone of pharmacokinetic optimization.
Molecular Obesity and Lipophilicity: Optimizing Drug Discovery for Next-Generation Therapies
This article explores the critical intersection of molecular obesity mechanisms and lipophilicity in modern drug discovery.