Research Articles
A Comparative Assessment of Molecular Docking Software: A Guide for Researchers and Drug Developers
This article provides a comprehensive comparative assessment of molecular docking software, a cornerstone tool in modern computational drug discovery.
Target Validation Techniques: A Comprehensive Guide for Drug Development Success
This article provides a detailed comparison of target validation techniques, a critical process in drug discovery that confirms a biological target's role in disease and its potential for therapeutic intervention.
Strategic Prodrug Design and Formulation: Enhancing Solubility, Permeability, and Targeted Delivery
This article provides a comprehensive overview of modern prodrug strategies for researchers and drug development professionals.
Mastering Solvation Effects in Structure-Based Drug Design: From Theory to Clinical Application
This article provides a comprehensive guide for researchers and drug development professionals on handling solvation effects in Structure-Based Drug Design (SBDD).
Beyond Rigid Locks: Solving Protein Flexibility to Revolutionize Molecular Docking in Drug Discovery
This article provides a comprehensive overview of the critical challenge of protein flexibility in molecular docking and the advanced computational strategies developed to address it.
Combatting Drug Resistance: From Molecular Mechanisms to AI-Driven Clinical Solutions
This article provides a comprehensive analysis of the evolving challenge of drug resistance, a critical barrier in treating infectious diseases and cancers.
Overcoming Poor Metabolic Stability in Drug Discovery: Strategies, Assays, and Future Directions
Poor metabolic stability remains a major cause of failure in drug development, leading to unfavorable pharmacokinetics, low bioavailability, and rapid clearance.
Strategies for Reducing Off-Target Effects and Toxicity in Drug Discovery and Gene Editing
This article provides a comprehensive guide for researchers and drug development professionals on managing off-target effects and toxicity, critical challenges in therapeutic development.
Breaking the Bioavailability Barrier: Advanced Strategies to Enhance Drug Solubility and Permeability
This article provides a comprehensive guide for researchers and drug development professionals tackling the pervasive challenge of poor bioavailability.
In Silico ADMET Prediction: A Comprehensive Guide to Methods, Applications, and Best Practices in Drug Discovery
In silico ADMET prediction has become an indispensable tool in modern drug discovery, enabling researchers to assess the absorption, distribution, metabolism, excretion, and toxicity properties of compounds early in the...