Research Articles
Managing Confounding by Indication in Observational Drug Studies: Advanced Methods and Practical Applications for Researchers
This article provides a comprehensive guide for researchers and drug development professionals on managing the pervasive challenge of confounding by indication in observational studies.
Addressing Heterogeneity in Network Meta-Analysis of Drugs: A Comprehensive Guide from Detection to Decision-Making
This article provides a comprehensive framework for researchers and drug development professionals to address heterogeneity in network meta-analysis (NMA).
Beyond Plasma: Integrating Structure–Tissue Exposure/Selectivity Relationship (STR) for Smarter Drug Optimization
With a 90% failure rate in clinical drug development, often due to insufficient efficacy or unmanageable toxicity, the pharmaceutical industry is re-evaluating its lead optimization paradigms.
Quantitative Synthesis Methods for Drug Safety and Efficacy: A Modern Framework for Evidence-Based Development
This article provides a comprehensive overview of quantitative evidence synthesis methods essential for robust assessment of drug safety and efficacy.
Using Physician Prescribing Preference as an Instrumental Variable: A Comprehensive Guide for Causal Inference in Clinical Research
This article provides a comprehensive overview of the use of Physician Prescribing Preference (PPP) as an instrumental variable (IV) in comparative effectiveness research and pharmacoepidemiology.
Beyond the Average: A Strategic Framework for Handling Heterogeneity in Comparative Drug Efficacy Studies
This article provides a comprehensive guide for researchers and drug development professionals on navigating clinical heterogeneity and Heterogeneity of Treatment Effects (HTE) in comparative effectiveness research.
Optimal Control Methods for Optimizing Combination Drug Regimens: From Mathematical Models to Clinical Translation
Combination therapies are a cornerstone of modern treatment for complex diseases like cancer, autoimmune disorders, and Alzheimer's, but optimizing their dosing and scheduling presents significant challenges.
Real-World Evidence for Drug Effectiveness: A Guide to Regulatory-Grade Study Designs and Methodologies
This article provides a comprehensive guide for researchers and drug development professionals on designing and implementing robust real-world evidence (RWE) studies to demonstrate drug effectiveness.
Propensity Score Methods in Pharmacoepidemiology: A Modern Guide to Confounding Control and Causal Inference
This article provides a comprehensive overview of the application of propensity score (PS) methods in pharmacoepidemiology, targeting researchers and drug development professionals.
Bayesian Mixed Treatment Comparisons: A Comprehensive Guide for Evidence Synthesis in Drug Development
This article provides a comprehensive guide to applying Bayesian models for Mixed Treatment Comparisons (MTC), also known as Network Meta-Analysis, in biomedical and pharmaceutical research.